Wellbutrin: Common Uses, Dosage, Side Effects and Precautions

Wellbutrin, under the brand name bupropion, is a prescription drug used to treat depression. It helps improve your mood and well-being. It works by helping restore the balance of certain neurotransmitters in your brain.
It is also used to treat SAD (seasonal affective disorder), another type of depression that is usually associated with fall and winter seasons.
Wellbutrin, under the name Zyban, has also been used to help people quit smoking.

Dosage and Directions

Wellbutrin is taken by mouth usually three times a day with or without food. If you experience stomach upset, you may take it with food. It’s recommended to take each dose after 6 hours to reduce the risk of developing a seizure.
Do not take more or less of the recommended dosage. Do not take more than 150mg in a single dose and do not take more than 450mg per day.
Your daily dosage depends on your medical condition and response to the medication. However, your dose may increase slowly to limit the occurrence of side effects and reduce the risk of seizures. To avoid insomnia, do not take this medication just before going to bed.


This medication may contain inactive allergen-causing ingredients. Inform your doctor of any allergies you have before taking it.
Let your doctor know about your medical history, especially if you have seizures or have conditions that can increase your risk of developing seizures such as diabetes, high blood pressure, heart disease, kidney and liver problems, history of glaucoma, brain or head injury/tumor or alcohol dependence.


Do not drink alcohol when taking this medication. During pregnancy, this medication should only be taken under the advice of a doctor.

Possible Side Effects

Headache, dry mouth, constipation, nausea, vomiting, joint pains, blurred vision, dizziness, diarrhoea, increased sweating and sore throat may occur. If you experience any of these side effects, notify your doctor promptly.
This is not the complete list of side effects. If you notice other side effects, inform your doctor as soon as possible.

Drug Interactions

Let your doctor know about any other drugs you are using. Do not start or stop any medicines without approval from your doctor.
Some products that may possibly interact with this medication include tamoxifen, codeine and pimozide.
Taking MAO inhibitors with Wellbutrin may result in fatal drug interactions. Do not take MAO inhibitors such as phenelzine, rasagiline, selegiline, moclobemide and procarabazine when taking this medication. Do not also take this medication two weeks before or after using MAO inhibitors.
This medication may interfere with certain laboratory tests including urine screen for amphetamines and brain scan for Parkinson’s disease, resulting in false results. Let the laboratory technician know if you are using this medication.

Missed Dose

If you miss a dose, skip that dose and take the next dose when it’s time. Do not take a double dose to compensate for the missed one.


An overdose of this medication is considered mildly dangerous. Symptoms of an overdose usually include vomiting, seizures, hallucinations and rapid heart rate.
Call a poison centre if you think you may have overdosed. If the person taking this medication has collapsed, call 911 immediately. The safety of Wellbutrin on children under 18 years and people older than 65 years is not known.


Store this medication at room temperature between 20-25 degrees Celsius (68 to 77 degrees Fahrenheit) in a dry, cool place away from sunlight.




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